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  • Probing the function of key proteins | MIT News

    “Kinase inhibitor” drugs, which target a class of enzymes that are crucial to kee

    cells running, make u

    one of the great success stories of modern medicine.

    “When kinase

    roteins go wrong, cells go wrong,” says Barbara Imperiali, the Class of 1922 Professor of Biology and

    rofessor of chemistry at MIT. “So the aberrant behavior of kinases is often targeted as a therapeutic strategy.”

    Although dozens of kinase inhibitors are now being investigated to treat cancers and other diseases, with associated development costs in the billions of dollars, the tools researchers employ to assess how well a drug compound actually engages a target kinase

    rotein are far from ideal.

    However, a

    owerful new a

    roach for analyzing these interactions, developed in Imperiali’s lab, is now being c


    全文(Full Article): https://news.mit.edu/2017/probing-function-key-proteins-barbara-imperiali-0112?groupid=28.9937.81433.81461&pid=1280273&startgroup=